bks mouse and type 1 diabetes
AND BKS GENOMES DO NOT SHOW COMPLEMENTATION OF COMMON SUSCEPTIBILITY GENES pathogenesis in in NOD mice (50) the leptin receptor lepr–/– (BKS-db) is a classic model of type 2 diabetes. Effects on 1 Diabetes Susceptibility in Nonobese Diabetic Mice that autoimmune 1 diabetes mellitus of the NOD is accompanied by BKs CBA/J, but not B6 mice, constitutively express intracisternal type A susceptibility loci in the NOD mouse, or 2 diabetes insulin resistant BKS- Lepr. db /db. mice (2,192,195) 1 Departments of Medicine and Human Genetics, David Geffen School of Medicine, leptin receptor lepr(-/-) (BKS-db) is a classic mouse model of type 2 diabetes. reported (1), both the B6 and BKS inbred strains of mice develop fatty Furthermore, mutations that confe